EXPERIMENTAL EMPHYSEMA
نویسندگان
چکیده
منابع مشابه
Effect of human antileucoprotease on experimental emphysema.
Antileucoprotease (ALP), a potent inhibitor of human neutrophil elastase (HNE), may be a modulating factor in the pathogenesis of emphysema. Investigating the clearance of intratracheally-instilled ALP in hamsters, we observed a rapid clearance from the airway lumen within 60 min, whereafter the remaining 40% slowly decreased with a calculated half-life (T0.5) of 2.8 h. Lung tissue-associated A...
متن کاملEffect of a cysteinyl leukotriene receptor antagonist on experimental emphysema and asthma combined with emphysema.
The incidence of overlapping bronchial asthma and chronic obstructive pulmonary disease has increased in recent years. Cysteinyl leukotrienes (CysLTs) play an important role in asthma, and the type 1 CysLT receptor (CysLT1R) is expressed by many inflammatory cells. We evaluated the effect of montelukast, a CysLT1R antagonist, on mouse models of asthma, porcine pancreatic elastase (PPE)-induced ...
متن کاملThe role of bacteria in experimental chronic bronchitis and emphysema.
The development of animal model systems in which hypotheses regarding a human disease counterpart can be tested should enable the independent evaluation of variables in a multifactorial system. This is particularly germane in a consideration of chronic obstructive lung disease since chronic bronchitis and emphysema may occur in combination or independently of the other, and since a number of ag...
متن کاملGhrelin therapy improves lung and cardiovascular function in experimental emphysema
BACKGROUND Emphysema is a progressive disease characterized by irreversible airspace enlargement followed by a decline in lung function. It also causes extrapulmonary effects, such as loss of body mass and cor pulmonale, which are associated with shorter survival and worse clinical outcomes. Ghrelin, a growth-hormone secretagogue, stimulates muscle anabolism, has anti-inflammatory effects, prom...
متن کاملSuggested criteria for confirming pulmonary emphysema in the experimental animal.
The investigator attempting to produce pulmonary emphysema in the experimental animal faces the problem of the criteria to be used in determining whether he has truly produced emphysema in his animal model. This of course partly depends upon his interpretation of the word emphysema-i.e., whether he understands it in the broadest sense as including all conditions of increased air in the lung, or...
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ژورنال
عنوان ژورنال: Archives of Internal Medicine
سال: 1919
ISSN: 0003-9926
DOI: 10.1001/archinte.1919.00090260087007